RecruitingNot Applicable

Impact of Sinus Surgery on Individuals With Cystic Fibrosis

United States170 participantsStarted 2020-07-01

Plain-language summary

This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be enrolled to serve as a control group. Outcomes analyzed will include pulmonary, quality of life, and others.

Who can participate

Age range18 Years – 99 Years

SexALL

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Inclusion criteria

✓. Subjects between the ages of 18 years old (inclusive) and 99 years old (inclusive, subjects over the age of 89 will be recorded to be 89 years old).
✓. Diagnosed with cystic fibrosis as established by genetic testing combined with clinical assessment and/or sweat chloride
✓. Diagnosed with chronic rhinosinusitis by multidisciplinary sinusitis guidelines
✓. chronic rhinosinusitis symptoms persisting beyond initial medical treatment
✓. Counseled for endoscopic sinus surgery and ongoing medical therapy with each patient electing their preferred treatment

Exclusion criteria

✕. Underwent endoscopic sinus surgery in past 12 months
✕. Will obtain follow up care at non-participating institutions
✕. Unable to complete follow-up surveys

What they're measuring

Change in pulmonary function

Timeframe: baseline, 3, 6, 9, 12 months

Change in days of inpatient hospitalization

Timeframe: baseline, 3, 6, 9, 12 months

Trial details

NCT IDNCT04469439

SponsorUniversity of California, Los Angeles

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-01-31

Contact for this trial

Daniel M Beswick, MD

310-206-8457 dbeswick@mednet.ucla.edu

View on ClinicalTrials.gov More Chronic Rhinosinusitis (Diagnosis) trials