INTRODUCTION: Iron is a vital nutrient for many physiological processes including DNA production, oxygen transport and neuronal processes. However, several factors limit iron absorption including: limited bioavailability of iron (dietary or supplementation sources), can be subject to dietary iron inhibitors (e.g. calcium). Excess iron can cause cellular oxidative stress in the body. Curcumin is an active component found in turmeric, known for its anti-oxidant and anti-inflammatory properties. Co-administration of iron and curcumin may influence iron, inflammatory status and/or neurotrophic markers in the body.
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To assess the influence of HydroCurc™ administration on ferrous iron supplementation associated inflammation
Timeframe: Change in Interleukin 6, Interleukin 10 and Interleukin 1 beta (ELISA) from day 1 compared to day 21 (baseline to midpoint), day 1 compared to day 42 (baseline to endpoint) and day 21 compared to day 42 (midpoint to endpoint)
To assess the influence of HydroCurc™ administration on ferrous iron supplementation associated inflammation
Timeframe: Change in Tumour Necrosis Factor alpha (ELISA) from day 1 compared to day 21 (baseline to midpoint), day 1 compared to day 42 (baseline to endpoint) and day 21 compared to day 42 (midpoint to endpoint)
To assess the influence of HydroCurc™ administration on ferrous iron supplementation associated inflammation
Timeframe: Change in C-Reactive Protein (immunoassay) from day 1 compared to day 21 (baseline to midpoint), day 1 compared to day 42 (baseline to endpoint) and day 21 compared to day 42 (midpoint to endpoint)
To assess the influence of HydroCurc™ administration on ferrous iron supplementation associated lipid peroxidation
Timeframe: Change in thiobarbituric acid reactive substances (ELISA) from day 1 compared to day 21 (baseline to midpoint), day 1 compared to day 42 (baseline to endpoint) and day 21 compared to day 42 (midpoint to endpoint)
To assess the influence of HydroCurc™ administration on ferrous iron supplementation associated acute iron absorption
Timeframe: Change in serum iron (colorimetric analyser) from 0 and 180 minutes following supplementation
To assess the influence of HydroCurc™ administration on ferrous iron supplementation associated acute iron absorption
Timeframe: Change in total iron binding capacity (colorimetric analyser) from 0 and 180 minutes following supplementation
To assess the influence of HydroCurc™ administration on ferrous iron supplementation associated iron status
Timeframe: Change in serum iron (colorimetric analyser) from day 1 compared to day 21 (baseline to midpoint), day 1 compared to day 42 (baseline to endpoint) and day 21 compared to day 42 (midpoint to endpoint)
To assess the influence of HydroCurc™ administration on ferrous iron supplementation associated iron status
Timeframe: Change in total iron binding capacity (colorimetric analyser) from day 1 compared to day 21 (baseline to midpoint), day 1 compared to day 42 (baseline to endpoint) and day 21 compared to day 42 (midpoint to endpoint)
To assess the influence of HydroCurc™ administration on ferrous iron supplementation associated iron status
Timeframe: Change in ferritin (immunoassay) from day 1 compared to day 21 (baseline to midpoint), day 1 compared to day 42 (baseline to endpoint) and day 21 compared to day 42 (midpoint to endpoint)
To assess the influence of HydroCurc™ administration on ferrous iron supplementation associated iron status
Timeframe: Change in haemoglobin (whole blood analyser) from day 1 compared to day 21 (baseline to midpoint), day 1 compared to day 42 (baseline to endpoint) and day 21 compared to day 42 (midpoint to endpoint)
To assess the influence of HydroCurc™ administration on ferrous iron supplementation associated iron status
Timeframe: Change in red blood cells (whole blood analyser) from day 1 compared to day 21 (baseline to midpoint), day 1 compared to day 42 (baseline to endpoint) and day 21 compared to day 42 (midpoint to endpoint)