The objectives of this proposal are to: 1) determine the rate of SARS-CoV-2 seroconversion in unselected pregnant women in Hong Kong; 2) determine the rate of SARS-CoV-2 infection in women presenting with miscarriage and stillbirth; 3) follow the pregnancy course and perinatal outcome of confirmed COVID-19-infected pregnant cases; 4) determine the risk and characteristics of vertical transmission; and 5) evaluate the placental barrier, immune response and fetal damage in vertical transmission of SARS-CoV-2. A series of longitudinal and cross-sectional observational studies, and a laboratory-based study will be conducted to fulfil the 5 objectives.
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Seroconversion during pregnancy - DSS1
Timeframe: At DSS1 (Around 11-13 weeks gestation)
Seroconversion during pregnancy - At delivery
Timeframe: At Delivery
Pregnancy loss
Timeframe: At pregnancy loss
Pregnancy course and perinatal outcome
Timeframe: From date of recruited until the date of delivery
Vertical transmission
Timeframe: At Newborn 0 hours of life, mother immediately after delivery
Vertical transmission
Timeframe: At Newborn 7 days of life
Vertical transmission
Timeframe: At Newborn 14 days of life
Vertical transmission
Timeframe: At Newborn 6 months of life
Vertical transmission
Timeframe: At Newborn 18 months of life
Potential mechanisms for vertical transmission 1) placental barrier, 2) immune response and 3) fetal damage of vertical transmission and mechanism in SARS-CoV-2 infection.
Timeframe: through study completion, up to 2 years