Statin Therapy to Reduce Progression in Women With Platinum Sensitive Ovarian Cancer

Inclusion Criteria: * Recurrent platinum sensitive ovarian cancer, all histologies (serous, endometrioid, mucinous, clear cell). Platinum sensitivity defined as ≥ 6 months since last platinum treatment. * No contraindication to carboplatin and/or liposomal doxorubicin or simvastatin. Exclusion Criteria: * Prior or current use of any statin medication * Current systemic use of medications known to interact with statins * Current use of any other investigational agents * Liver disease, active cirrhosis * Uncontrolled intercurrent illness * History of chronic myopathy * Prior cancer other than ovarian cancer or non-melanomatous skin cancers * Known active infection with HIV * Current excessive alcohol consumption (average alcohol consumption of more than 5 drinks per day) * Prior exposure to doxorubicin or liposomal doxorubicin * Hemoglobin A1C \>8.0%