BCG and Plasma Amyloid in Non-Demented Adults

Inclusion Criteria: * BCG naive * Ability to read, understand and sign consent form Exclusion Criteria: * Known allergy to (components of) the BCG vaccine or serious adverse events to prior vaccine administration * Known active or latent Mycobacterium tuberculosis or with another mycobacterial species. A history of - or a suspicion of M. tuberculosis infection. * Fever (\>38 C) within the past 24 hours. * Suspicion of active viral or bacterial infection. * Vaccination in the past 4 weeks or expected vaccination during the study period, independent of the type of vaccination. * Severely immunocompromised subjects. This exclusion category comprises: a) subjects with known infection by the human immunodeficiency virus (HIV-1); b) neutropenic subjects with less than 500 neutrophils/mm3; c) subjects with solid organ transplantation; d) subjects with bone marrow transplantation; e) subjects under chemotherapy; f) subjects with primary immunodeficiency; g) severe lymphopenia with less than 400 lymphocytes/mm3; h) treatment with any anti-cytokine therapies. i) treatment with oral or intravenous steroids defined as daily doses of 10mg prednisone or equivalent for longer than 3 months, or probable use of oral or intravenous steroids in the following four weeks. * Active solid or non-solid malignancy or lymphoma within the prior two years.