The microbiome of 80 orthopedic-device related infection (ODRI) patients treated with antibiotics and 10 healthy controls will be investigated. Samples (blood, stool, saliva, skin-swab) are collected 4x within 6 months. Composition and diversity of the microbiome will be assessed by 16sRNA sequencing, skins swabs are screened for rifampicin-resistant staphylococci onto Mannitol-salt-agar plates supplemented with rifampicin, inflammation markers and antibodies in blood and saliva are monitored to track changes in the immune response. For further analysis patients are assigned to one of two groups: 1) antibiotic therapy including rifampicin and 2) non-rifampicin antibiotic therapy.
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Composition of the the gut microbiota following two weeks of intravenous antibiotic therapy
Timeframe: Two weeks
Composition of the gut microbiota following four weeks of oral antibiotic therapy
Timeframe: Six weeks (including two weeks iv and four weeks of oral antibiotic therapy)
Composition of the gut microbiota 24 weeks after antibiotic therapy start
Timeframe: 24 weeks