Prospective Evaluation of Confirmatory Testing for Primary Aldosteronism

Inclusion Criteria: * Individuals with hypertension * Individuals with an elevated screening adrenal renin ration (ARR) * Individuals with high probability features of primary aldosteronism (e.g., resistant hypertension, spontaneous or diuretic-induced hypokalemia, and/or an adrenal nodule) with clinical indications for adrenal vein sampling and surgery (if appropriate). Exclusion Criteria: * Individuals with chronic kidney disease (estimated glomerular filtration rate \<40 mL/min/1.73m2), * Individuals with a history of heart failure, chronic edema, uncontrolled severe hypertension (systolic blood pressure \>180 and/or diastolic blood pressure \>110 mmHg), untreated hypokalemia, cortisol-secreting adrenal adenoma, and/or pheochromocytoma * Individual who previously received confirmatory testing.