Efforts in curing and preventing obesity and type 2 diabetes (T2D) have been elusive thus far. One reason for that is the lack of understanding of the role of the brain in the development and treatment of the disease. In recent studies, the hypothalamus was identified as part of a brain network including higher cognitive regions that is particularly vulnerable to insulin resistance. Furthermore, the central insulin response in this network predicted food craving and hunger. In this project, transcranial direct current stimulation (tDCS) is implemented as a tool to stimulate brain networks. The investigators hypothesize that stimulating the hypothalamus-cognitive network will enhance insulin sensitivity and reduce food intake, food craving and hunger. Furthermore, the project will provide the unique opportunity to investigate novel mechanisms of insulin resistance in participants who have been extensively metabolically characterized.
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Peripheral insulin sensitivity
Timeframe: 1 day after last intervention tDCS day
Caloric intake (kcal)
Timeframe: 1 hour directly after tDCS stimulation
Change in subjective feeling of hunger and food craving
Timeframe: 5 minutes before tDCS stimulation, 5 minutes after tDCS stimulation and 5 minutes after buffet