Hydrolyzed Fish Cartilage Effect on Knee Joint Functionality and Discomfort in Adult Population

Inclusion Criteria: * Male or female * Age limits (see above) * Body Mass Index BMI ≤ 35 kg/m2 * Knee discomfort score at rest over the last 24 hours on the most painful knee evaluated on VAS (0-100) ≥ 40 at baseline * Able to follow the instructions of the study * Having signed an informed consent Exclusion Criteria: * related to knee: * Recent trauma (\< 1 month) of the knee responsible of the symptomatic knee; * Concurrent articular disease interfering with the evaluation of knee pain left to the Investigator's discretion * Prosthesis in the target knee * related to treatments: * Analgesics to manage knee pain 24 hours before inclusion visit; * Corticosteroids injection in the target knee in the last month; * Hyaluronan injection in the target knee in the last 6 months; * Arthroscopy in the last 6 months * Oral corticotherapy ≥ 5mg/day (in Prednisolone equivalent) in the last 3 months; * Symptomatic slow-acting drugs for osteoarthritis (SYSADOA) or dietary supplement, i.e., curcuma extract, chondroitin, glucosamine, diacerein or avocado-soya unsaponifiables int he last 3 months * Contraindications to Cartidyss: hypersensitivity or allergy to the product components (fish) * Treatments based on strontium ranelate, bisphosphonates, selective estrogen-receptor modulator (SERM) and parathormone (PTH) in the last 12 months * related to associated diseases : * Any severe, uncontrolled and limiting diseases left to the Investigator's discretion * An…