Stopped: The sponsor decided to close the study early due to low patient enrollment and the sponsor no longer pursuing stem cell therapy treatment.
This is a prospective, multi-location safety and effectiveness study, and data registry of autologous adult ADRCs generated by the Transpose® RT System in subjects with OA in the shoulder, wrist, knee, hip, or ankle.
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Safety as indicated by incidence (%) of unanticipated AEs. All AEs and SAEs will be graded on severity by the Investigator using the National Institutes of Health Common Terminology Criteria for Adverse Events (NIH CTCAE).
Timeframe: Up to 2 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the knee using PROMIS 10 Global health
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the knee using SF-12v2
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the knee using the Visual Analog Pain Scale (VAS-Pain)
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the knee using the Knee Osteoarthritis Outcome Score (KOOS)
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in the range of motion of the knee (ROM) measurements for the knee
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the shoulder using PROMIS 10 Global health
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the shoulder using SF-12v2
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the shoulder using the Visual Analog Pain Scale (VAS-Pain)
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the shoulder using American Surgeon and Elbow Surgeon (ASES) measure
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the shoulder using the Oxford Shoulder Score
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in the range of motion of the shoulder (ROM)
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the wrist using PROMIS 10 Global health
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the wrist using SF-12v2
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the wrist using the Pain Score Analog Scale (VAS-Pain)
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the wrist using the Quick-Dash
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the wrist using PROMIS-Upper Extremity
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in the range of motion of the wrist (ROM)
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the ankle using PROMIS 10 Global health
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the ankle using SF-12v2
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the ankle using the Pain Score on Visual Analog (VAS-Pain)
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the ankle using the Foot and Ankle Disability Index (FADI)
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in the range of motion of the ankle (ROM)
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the hip using PROMIS 10 Global health
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the hip using SF-12v2
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the hip using Pain Score on Visual Analog Scale (VAS-Pain)
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in patient reported outcomes (PRO) measurements for the hip using the Hip Disability Osteoarthritis Outcome Score (HOOS)
Timeframe: Through study completion, up to 3 years
Efficacy outcomes include changes in the range of motion of the knee (ROM) measurements for the hip
Timeframe: Through study completion, up to 3 years