CHAMPION-AF Clinical Trial

Inclusion Criteria: * The subject is of legal age to participate in the study per the laws of their respective geography * The subject has documented non-valvular atrial fibrillation (i.e., atrial fibrillation in the absence of moderate or greater mitral stenosis or a mechanical heart valve) * The subject has a calculated CHA2DS2-VASc (congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke or transient ischemic attack (TIA), vascular disease, age 65 to 74 years, sex category) score of 2 or greater for men and 3 or greater for women * The subject is deemed to be suitable for the protocol-defined pharmacologic regimens in both the test and control arms * The subject or legal representative is able to understand and willing to provide written informed consent to participate in the trial * The subject is able and willing to return for required follow-up visits and examinations Exclusion Criteria: * Subjects who are currently enrolled in another investigational study, except when the subject is participating in a mandatory governmental registry, or a purely observational registry with no associated treatments * The subject requires long-term anticoagulation therapy for reasons other than AF-related stroke risk reduction, for example due to an underlying hypercoagulable state (i.e., even if the device is implanted, the subjects would not be eligible to discontinue OAC due to other medical conditions requiring chronic OAC therapy) * The subject is contr…