A Study to Assess the Safety and Efficacy of ECF843 vs Vehicle in Subjects With Dry Eye Disease

Inclusion Criteria: * Written informed consent must be obtained before any assessment * Adult male or female subjects 18 years of age or older * At least 6 months history of dry eye disease in both eyes * Must use, or feel the need to use, artificial tears/gels/lubricants on a regular basis * Composite corneal fluorescein staining score \>= 4 (modified National Eye Institute (NEI) scale) in at least one eye * Schirmer score \>= 1 and =\< 10 mm after 5 minutes in at least one eye * Patients with Sjögren's Syndrome must have dry eye Exclusion Criteria: * Ocular infection in either eye within 30 days prior to Screening * Use of artificial tears, gels, lubricants within 4 hours of the Screening Visit * Use of contact lenses in either eye within 14 days of Screening * Uncontrolled ocular rosacea * Clinically significant conjunctivochalasis in either eye * Other Corneal conditions affecting the corneal structure * Severe ocular conditions such as herpes, graft versus host disease, Stephen's Johnson Syndrome, sarcoidosis * Currently active, or history of ocular allergies during the time of year the patient will be participating in the study * Patients with current punctal plugs or punctal cauterization or occlusion * Chronic medications (both over the counter and prescription) that have not been stable for at least 30 days prior to Screening. * Use of Restasis®, Cequa®, or Xiidra® within 30 days prior to Screening * Use of ocular, nasal, inhaled, or systemic corticosteroids withi…