Maneuver for Evaluating the Potential Recruitability of the Pulmonary Parenchyme in Patients With… (NCT04387669) | Clinical Trial Compass
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Maneuver for Evaluating the Potential Recruitability of the Pulmonary Parenchyme in Patients With ARDS
France42 participantsStarted 2020-04-12
Plain-language summary
This study will try to define the threshold of the recruitable volume (Vrec), obtained by a derecruitment maneuver, that permit to identify patients responder or not to alveolar recruitment maneuvers.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Moderate to severe ARDS as per the Berlin definition (Partial pressure of oxygen (PaO2)/Fraction of inspired oxygen (FiO2) \< 200 mmHg) and within 72h of onset, with a FiO2 \> 60%
* Receiving assist/control mechanical ventilation with continuous sedation and neuromuscular blocker
* In supine position during the procedures and measurements
* Patients \> 18 years of age
Exclusion Criteria:
* Patients \< 18 years of age
* Pregnant woman
* Patient deprived of freedom or under a legal protective measure
* Hemodynamic instability defined as a mean arterial pressure \< 65 mmHg or increasing doses of vasopressor drugs
* Pneumothorax, pneumomediastinum, pleural fistula, sub-cutaneous emphysema
* Chronic or recent severe cardiac dysfunction
* Patient with a PEEP \> 15 cmH20 before inclusion
* Patient with no therapeutic perspective; candidate for palliative care exclusively or with end of life decision before inclusion