Alveolar Socket Healing With and Without PRGF

Inclusion Criteria All of the following criteria must be fulfilled for inclusion: * Patient must have willingness to read and sign a copy of the Informed Consent Form Males and females, ≥25 years old. * Patient in need of a single permanent tooth extraction with clinical and/or radiographic evidence of unrestorable maxillary premolars, canines, or incisors with at least one adjacent tooth present, and with periodontal attachment preserved at least for 2/3rd of the root nor associated with acute periapical pathology. * Post-extraction alveolar bone defect with ≤50 % buccal bone loss. This will be confirmed at Visit 2 after extraction. In case of \>50% buccal bone loss, the participant will be withdrawn. * Patient in good general health as documented by self-assessment. * Full mouth bleeding and plaque scores (FMBS \<10% and FMPS \<20%) recorded within the previous 8 weeks. Exclusion criteria * Uncontrolled or untreated periodontal disease. * History of local (head and neck) radiation therapy. * Presence of oral lesions in the area of the extraction (such as ulceration, malignancy). * Severe bruxing or clenching habits. * Acute endodontic lesion in the test tooth or in the neighbouring areas to the extraction procedure (sites with presence of an asymptomatic chronic lesion are eligible). * Medical history that includes uncontrolled diabetes or hepatic or renal disease, or other serious medical conditions that can impact on bone metabolism (e.g. rheumatoid arthritis, osteopo…