PREvention of Intrauterine Adhesion After Hysteroscopic Surgery With Novel deGradable Film

Inclusion Criteria: * Women ≥ 40 years AND no childbearing wish, OR history of permanent sterilization; * Subject scheduled for hysteroscopic myomectomy for one or more myoma(s) where one myoma is at least 10 mm in size (≥10mm) as estimated by pre-operative ultrasound measurement of the largest diameter, * Hysterometry prior to device insertion ≥ 6cm and ≤ 9cm. * Subjects who are willing to provide a written informed consent as approved by the applicable Ethics Committee prior to participating in this clinical investigation. * Subjects who can comply with the study follow-up or other study requirements Exclusion Criteria: Pre-operative exclusion criteria: * Current pregnancy * Abnormal uterine cavity according to ESHRE classification I to VI, such as unicornis, bicornis, septate, duplex * Known or suspected endometrial hyperplasia * Medical history of cervical or endometrial cancer * Active pelvic infection or medical history of pelvic peritonitis * Intrauterine device in situ * Known contraindication or hypersensitivity to PEO or PLA, and to medications such as aspirin…. * Concurrent medical condition with a life expectancy of less than 12 months * Full endometrial ablation Per-operative exclusion criteria: * Adenomyosis * Inflammation (endometritis) * Abnormal uterine cavity * Hysterometry \< 6cm or \>9cm * Any complication during the intervention that is deemed to potentially interfere with the objective of the study by the investigator