Mesenchymal Stem Cells (MSCs) in Inflammation-Resolution Programs of Coronavirus Disease 2019 (COVID-19) Induced Acute Respiratory Distress Syndrome (ARDS)

Inclusion Criteria: * COVID-19-positive subject * Horowitz index ≤ 200 * Bilateral opacities on frontal chest radiograph, and * requirement for positive pressure ventilation via an endotracheal tube or non-invasive ventilation * no clinical signs of left atrial hypertension detected via echocardiography, or if measured, a Pulmonary Arterial Wedge Pressure (PAOP) less than or equal to 18 mmHg. * Subject's Age ≥ 18 years Exclusion Criteria: * COVID-19-negative subject * Subject's Age \< 18 years * More than 7 days since initiation of mechanical ventilation * Patient, surrogate or physician not committed to full intensive care support. * Positive Pregnancy test at the time of screening. * Patients dependent on the sponsor, investigator and their employees, as well as persons dependent on the manufacturer of the investigational drug