Prednisolone Treatment in Acute Interstitial Nephritis
Denmark110 participantsStarted 2017-09-01
Plain-language summary
A Prospective randomized trial with a primary objective to investigate the effect ofprdenisolone treatment in acute interstitial nephritis
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Biopsy verified AIN
* Clinical suspicion of AIN
* Age \> 18 years
* One of following criteria:
* Plasma creatinine \> 120 µmol/L or
* Plasma creatinine increase \> 30 µmol/L or increase \> 50 % of baseline plasma creatinine
* Fertile women are included
Exclusion Criteria:
* No ability to give informed consent
* Immunosuppressive treatment (including prednisolone) within 3 months before biopsy
* Autoimmune disease
* Prednisolone intolerance
* Pregnancy or lactation
* Active cancer (except basal cell carcinoma)
* Short life expectancy (\< 6 months)
* CKD stage IV-V
* AIN secondary to or accompanied by glomerulonephritis, sarcoidosis or inherited interstitial renal disease
* Previous participation Withdrawal criteria
* Development of exclusion criterion
* Withdrawal of consent