Asthma, which are one of the most important causes of morbidity and mortality both in the world and in our country, constitute a very serious social and economic burden. An estimated 300 million people suffer from asthma worldwide, which is a major public health problem. Asthma is complex and heterogeneous chronic airway diseases that require a multifaceted approach. In asthma, small airways represent key regions of airflow obstruction. Although small airway dysfunction is known in chronic airway diseases, the importance of small airway dysfunction on disease control, exacerbations and quality of life, and the importance of taking place among treatable targets is not clear. Thus, there is an unmet need to assess its role in the control of the disease. Therefore, our primary aim in the study is to determine the frequency of small airway dysfunction measured by impulse oscillometry in Asthma patients. Our secondary aim is to evaluate the role of small airway dysfunction in disease severity, disease phenotypes, disease control, quality of life and its effect on predicting the risk of exacerbation and its role among treatable targets in Asthma.
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Small airway dysfunction will be evaluated by performing impulse oscillometry test.
Timeframe: through study completion, an average of 1 year
Small airway dysfunction will be evaluated by thorax computed tomography.
Timeframe: through study completion, an average of 1 year
Small airway dysfunction will be evaluated by body plethysmography test.
Timeframe: through study completion, an average of 1 year
Symptom control will be evaluated by asthma control test.
Timeframe: through study completion, an average of 1 year
The number of moderate and severe exacerbations over a 1 year period will be recorded.
Timeframe: through study completion, an average of 1 year
Forced expiratory volume in 1 second (fev1) change will be evaluated by spirometric pulmonary function test.
Timeframe: through study completion, an average of 1 year