Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19) (NCT04374474) | Clinical Trial Compass
WithdrawnPhase 4
Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19)
Stopped: Study withdrawn before any enrollment (site's research goals adjustments).
Canada0Started 2021-01-10
Plain-language summary
The study will be a randomized controlled trial, involving patients with hyposmia/anosmia of onset immediately after an upper respiratory viral illness, assigned to three distinct study arms. Nasal irrigations will be prescribed to all three groups (BID). In addition, one arm will receive a paper hand-out about post-viral anosmia with instructions to smell common household items (current care) and act as a control group. The second group will receive an essential oil retraining kit, whereas the third group will receive the same olfactory training kit and a prescription to use budesonide with the nasal irrigations. Olfactory scores will be tested at the enrollment, 3 months and at 6 months.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults 18 years of age or older
* Hyposmia/anosmia of onset immediately after an upper respiratory viral illness confirmed on Snap n' Sniff threshold testing,
* Capable, in the opinion of the primary investigator, of providing informed consent to participate in the study. Participants are required to sign an informed consent form indicating they understand the purpose and nature of the study, and that they are willing to participate.
Exclusion Criteria:
* active cigarette smoker
* chronic rhinosinusitis
* head trauma with loss of consciousness
* inability to read/understand English
* previous hyposmia/anosmia complaint
* pregnancy
* previous sinus
* skull base or brain surgery
* current participation in another clinical trial at the time of initial visit
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change from Baseline Snap and Sniff Threshold Test at 3 months
Timeframe: 3 months
2
Change from baseline Smell Identification Test (SIT) at 3 months
Timeframe: 3 months
3
Change from Baseline Snap and Sniff Threshold Test at 6 months
Timeframe: 6 months
4
Change from baseline Smell Identification Test (SIT) at 6 months
Timeframe: 6 months
Trial details
NCT IDNCT04374474
SponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's