This study will validate a previously developed pediatric prognostic biomarker algorithm aimed at improving prediction of risk for the later development of chronic graft-versus-host disease (cGvHD) in children and young adults undergoing allogeneic hematopoietic stem cell transplant. By developing an early risk stratification of patients into low-, intermediate-, and high-risk for future cGvHD development (based upon their biomarker profile, before the onset of cGvHD), pre-emptive therapies aimed at preventing the onset of cGvHD can be developed based upon an individual's biological risk profile. This study will also continue research into diagnostic biomarkers of cGvHD, and begin work into biomarker models that predict clinical response to cGvHD therapies.
Age range
0 Years – 24 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Day 60 blood sample collection
Timeframe: Day 60 (+/- 7 days) post-transplant
Day 100 blood sample collection
Timeframe: Day 100 (+/- 14 days) post-transplant
Onset CvHD blood sample collection
Timeframe: The day of initial diagnosis
Baseline transplant clinical data collection at Day 0
Timeframe: Between day 0 (day of transplant) and day +21
Clinical data collection at Day 60
Timeframe: Day 60 (+/- 7 days) post-transplant
Clinical data collection at Day 100
Timeframe: Day 100 (+/- 14 days) post-transplant
Clinical data collection at 6 months
Timeframe: 6 Months (+/- 1 month) post-transplant
Clinical data collection at 12 months
Timeframe: 12 Months (+/- 1 month) post-transplant
Clinical data collection at 24 months
Timeframe: 24 Months (+/- 1 month) post-transplant
Clinical data collection at onset of GvHD
Timeframe: At the time of diagnosis