Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)

Inclusion Criteria: * Age 18-75 with history of chronic sinusitis without polyps * SNOT-22 score of at least 30 at baseline * Bilateral Lund-Mackay CT score 4 or more and/or MLK endoscopy score 4 or more * Blood eosinophil count of at least 300/ul and/or SPT positive to at least 5/30 allergens, or eosinophil less than 300/ul and SPT negative (Th2 low group). * Prior oral steroid or antibiotic use is acceptable but not required for entry * Informed Consent * Effective birth control (with \<1% failure rate), post menopausal or documented abstinence * Women ≥50 years old would be considered postmenopausal if they have been amenorrheic for 12 months or more following cessation of all exogenous hormonal treatment. * All male subjects who are sexually active must agree to use an acceptable method of contraception (condom or vasectomy) from V1-V16 Exclusion Criteria: * Immunosuppression other than oral steroids in the past 3 months * History of nasal polyps within the past 3 years or noted at screening by CT or endoscopy * Acute sinusitis at the time of entry * Acute fungal sinusitis at the time of entry * Uncontrolled asthma * Cystic fibrosis * Primary immune deficiency including CVID * Other; serious concomitant illness or sinus disease that the investigator determines to disqualify * A history of known immunodeficiency disorder including HIV * History of hepatitis B or C * Primary ciliary dyskinesia (PCD) * Use of any biologic medication within the last 5 months or 5 half-live…