Personalised Immunotherapy for SARS-CoV-2 (COVID-19) Associated With Organ Dysfunction

Inclusion Criteria: * Age equal to or above 18 years * Male or female gender * In case of women, unwillingness to remain pregnant during the study period. * Written informed consent provided by the patient or by one first-degree relative/spouse in case of patients unable to consent * Confirmed infection by SARS-CoV-2 virus using molecular techniques as defined by the World Health Organization11 * Organ dysfunction defined as the presence of at least one of the following conditions: * Total SOFA score greater than or equal to 2; * Involvement of the lower respiratory tract * Laboratory documentation of MAS or immune dysregulation. MAS is documented by the findings of any serum ferritin greater than 4,420ng/ml. immune dysregulation is documented by the combination of two findings: a) serum ferritin equal to or lower than 4,420ng/ml; and b) less than 5,000 receptors of the membrane molecule of HLA-DR on the cell membrane of blood CD14-monocytes or less than 30 MFI of HLA-DR on the cell membrane of blood CD14-monocytes as counted by flow cytometry Exclusion Criteria: * Age below 18 years * Denial for written informed consent * Any stage IV malignancy * Any do not resuscitate decision * Active tuberculosis (TB) as defined by the co-administration of drugs for the treatment of TB * Infection by the human immunodeficiency virus (HIV) * Any primary immunodeficiency * Oral or IV intake of corticosteroids at a daily dose equal or greater than 0.4 mg prednisone or greater the la…