Embryo Selection by Noninvasive Preimplantation Genetic Test (NCT04339166) | Clinical Trial Compass
CompletedNot Applicable
Embryo Selection by Noninvasive Preimplantation Genetic Test
China1,152 participantsStarted 2020-04-16
Plain-language summary
The objective of this study is to explore whether non-invasive chromosome screening (NICS) can be used as an effective indicator for embryos selection besides morphology through a multicenter randomized controlled trial, by comparing the differences of live birth rate, pregnancy rate and miscarriage rate between the two groups of embryo selection by "NICS+ morphology" and embryo selection only by "morphology" in IVF cycle.
Who can participate
Age range35 Years – 42 Years
SexFEMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
✓. Women receiving controlled ovarian hyperstimulation treatment (including ultra-long protocol、long-protocol 、short protocol treatment with GnRH agonist and GnRH antagonist treatment protocol); and the number of oocytes ≥6; The female BMI is from 18 to 30kg/m2.
✓. Culture embryos to blastocyst stage and all the blastocysts will be single cryopreserved.
✓. Single frozen-thawed blastocyst Transferred for the first time
✓. The number of blastocysts ≥2, morphology grade (above 4BC/4CB)
✓. Written informed consent
Exclusion criteria
✕. One of couples with IVF or ICSI contraindications(such as poorly controlled type I or type II diabetes; liver disease or dysfunction; kidney disease or renal function abnormality; significant anemia; history of deep venous thrombosis, pulmonary embolus; history of cerebrovascular accident; uncontrolled hypertension or diagnosed heart disease; history of cervical, endometrial or breast cancer; undiagnosed vaginal bleeding.)
✕. PGT cycles
✕. Women who have pathologies or malformations that affect the pregnancy outcome: genital malformations, untreated hydrosalpinx, untreated uterine infections, intramural myomas \> 4cm , benign tumor of pelvic and abdominal cavity\> 4cm, intimal thickness\<8mm, pituitary tumors and malignant tumors of various tissues and organs during the patient's participation in the study
What they're measuring
1
Ongoing pregnancy rate
Timeframe: 12 weeks after the first embryo transfer