Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantation

Inclusion Criteria: * All disease indications for allogeneic hematopoietic cell transplantation except for myelofibrosis. * Subject must meet program eligibility criteria\* for myeloablative conditioning alloHCT and plan to undergo myeloablative conditioning. * HLA-identical related donor or unrelated human donor source with bone marrow graft. * Subjects must provide a written informed consent. Exclusion Criteria: * History of allergy or intolerance to NR precursor compounds, including niacin or nicotinamide * Pregnant or breastfeeding women are excluded from this study since allogeneic HCT is a strict contraindication. * Subjects with uncontrolled intercurrent illness or psychiatric illness/social situations that would limit compliance with study requirements.