Dopaminergic RestauratIon by IntraVEntriculaire Administration

Inclusion Criteria: * Parkinson\'s disease at the stage of L-dopa-induced severe motor and non-motor complications * Men or women over 18 years old * Parkinson\'s disease according to MDS criteria * Severe motor complications including motor fluctuations with at least 2 hours of Off and 1 hour of dyskinesias uncontrolled by optimized oral drug therapy, i.e. with at least 5 doses of L-dopa and the addition or trial of a dopaminergic agonist (if tolerated) per os or by apomorphine pump * The patient meets the criteria for a second-line invasive treatment such as deep brain stimulation (subthalamic or medial pallidum) or intrajejunal administration of levodopa gel (Duodopa®). * Patients with a contraindication or who prefer this invasive therapeutic alternative to the other two existing and validated therapies (subthalamic stimulation or Duodopa®) because of its advantages: lower theoretical risk of intracerebroventricular delivery compared to subthalamic stimulation and better ergonomics than Duodopa®, but with the disadvantage of an as yet unproven benefit. * Social security * Able to provide free and informed consent to participate in research * Patient willing to comply with all study procedures and duration * Patient not planning to change lifestyle (nutritionally, physically or socially) during study participation Exclusion Criteria: * Over 75 years of age * Subjects not receiving at least 5 doses per day of oral dopaminergic therapy * Subject without a prior tr…