WithdrawnNot Applicable

The DURATION Study: reDUcing sedentaRy behAviour to Maintain cogniTIve functiON.

Stopped: Principal investigator moved to a different role

Canada0Started 2025-12-01

Plain-language summary

Rationale: Older adults spend the majority of their time in sedentary behaviours (SB). High amounts of SB have been correlated with reduced cognitive performance. Long periods of time spent sitting results in excessive glycemic variability, potentially contributing to cognitive decline. Reducing/replacing SB with short intermittent bouts of light physical activity have shown positive effects on glycemic variability. Thus, interrupting prolonged sitting with bouts of light physical activity may regulate blood glucose and thus mitigate cognitive decline. Purpose: This study intends to investigate the appropriate interval frequency of post-prandial SB reduction, by light physical activity needed to optimize total and incremental area under the curve for glucose response in overweight older adults at risk for glucose intolerance with mild cognitive impairment in both lab and free-living environments. Second, this study aims to investigate the acute impact of reducing SB on glycemic variability and its relationship with cognition. Hypothesis: First, there will be a dose-dependent response of more frequent interruptions of SB (more frequent intervals of light physical activity) with better glycemic control. Second, reducing SB will result in less glycemic variability, which will translate into better levels of cognitive performance. Methods: Generalized linear mixed models with random intercepts will be used to evaluate the differential effects of the experimental conditions on the selected outcomes.

Who can participate

Age range65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 65 years * Have a caregiver that works with you at least 20 hours a week (needs to be present for the familiarization session (explained below) and drop-off and pick-up from lab sessions) * Diagnosis of diabetes by a healthcare provider (e.g. family doctor). * Diagnosis of MCI by a healthcare provider * Self-report being physically inactive (not meeting the current PA guidelines of 150 min MVPA/week) * Self-report being sedentary- (defined as self-reported sedentary time ≥ 7 h/day) * Able to walk one block without an assistive device * Own a smartphone with unlimited outgoing text messages and access to internet connection. The smartphone must be either iphone 7 (with iOS of 12.2 or higher) or Android operating system 5 or higher to allow for Libre View mobile application compatibility. * Able to read, write and understand English Exclusion Criteria: * Currently smoke * Depression (Geriatric Depression Score short-form \> 6 (GDS)) (Yesavage, Brink, Rose, \& et al, 1983). * Medication: hypoglycemics; antilipidemics; antidepressants; beta blockers; anti-anxiety agents * Peri-menopausal or menopausal women (must be post-menopausal) * Excessive alcohol consumption (\> 8 points on the Alcohol Use Disorders Identification Test) * Uncontrolled hypertension (measured systolic \> 140 mmHg or diastolic \> 90 mmHg)

What they're measuring

Glycemic Variability

Timeframe: 1-7 days

Trial details

NCT IDNCT04323423

SponsorWestern University, Canada

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-01