Uterus Transplantation Procedure From a Live Donor (NCT04314869) | Clinical Trial Compass
UnknownNot Applicable
Uterus Transplantation Procedure From a Live Donor
Spain10 participantsStarted 2020-05-23
Plain-language summary
Absolut uterine factor, meaning the absence of uterus, represents a cause for sterility without the possibility of a present treatment. The uterine factor affects millions of women and may be due to congenital problems, such as the Muller anomalies (Mayer Rockitansky Syndrome) or acquired by previous hysterectomy or intrauterine adhesions (Asherman's Syndrome). The uterine transplant would represent the only possibility for patients with an absolute uterine factor to achieve both genetic and gestational maternity.
Who can participate
Age range18 Years – 65 Years
SexFEMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria Recipient:
* Patient with sterility for absolute uterine factor (malformation or previous surgery for benign processes).
* Age \<40 years.
* Absence of pathology that contraindicates a complex surgical process, immunosuppression or gestation.
* Positive results to the IVF cycle prior to the surgery, obtaining quality embryos.
* Acceptance to participate in the study signing the informed consent.
Exclusion Criteria Recipient:
* Medical or surgical pathology that contraindicates a complex pelvic surgical procedure.
* Medical conditions that contraindicate, may aggravate or complicate the immunosuppressor treatment, such as neoplastic or preneoplasic diseases, chronic infectious diseases, autoimmune diseases, renal or liver failure.
* Medical or surgical pathology that contraindicates pregnancy.
* Anatomic alterations or vascular pathology that might difficult the vascular anastomosis: severe endometriosis, pelvic kidney, severe adherence syndrome or others.
* Uncontrolled psychopathology.
Inclusion Criteria donor:
* Age \<65 years.
* First- or second-degree relatives.
* Completed reproductive desire.
* History of previous pregnancies and births.
* Absence of associated pathology that contraindicates prolonged and complex laparoscopic surgery (pneumopathies, heart disease, morbid obesity, …).
* Acceptance to participate in the study signing the informed consent
Exclusion Criteria donor:
* Potential future pregnancy desire.
* Surgery for the treatment of…