UnknownNot Applicable

Uterus Transplantation Procedure From a Live Donor

Spain10 participantsStarted 2020-05-23

Plain-language summary

Absolut uterine factor, meaning the absence of uterus, represents a cause for sterility without the possibility of a present treatment. The uterine factor affects millions of women and may be due to congenital problems, such as the Muller anomalies (Mayer Rockitansky Syndrome) or acquired by previous hysterectomy or intrauterine adhesions (Asherman's Syndrome). The uterine transplant would represent the only possibility for patients with an absolute uterine factor to achieve both genetic and gestational maternity.

Who can participate

Age range

18 Years – 65 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria Recipient: * Patient with sterility for absolute uterine factor (malformation or previous surgery for benign processes). * Age \<40 years. * Absence of pathology that contraindicates a complex surgical process, immunosuppression or gestation. * Positive results to the IVF cycle prior to the surgery, obtaining quality embryos. * Acceptance to participate in the study signing the informed consent. Exclusion Criteria Recipient: * Medical or surgical pathology that contraindicates a complex pelvic surgical procedure. * Medical conditions that contraindicate, may aggravate or complicate the immunosuppressor treatment, such as neoplastic or preneoplasic diseases, chronic infectious diseases, autoimmune diseases, renal or liver failure. * Medical or surgical pathology that contraindicates pregnancy. * Anatomic alterations or vascular pathology that might difficult the vascular anastomosis: severe endometriosis, pelvic kidney, severe adherence syndrome or others. * Uncontrolled psychopathology. Inclusion Criteria donor: * Age \<65 years. * First- or second-degree relatives. * Completed reproductive desire. * History of previous pregnancies and births. * Absence of associated pathology that contraindicates prolonged and complex laparoscopic surgery (pneumopathies, heart disease, morbid obesity, …). * Acceptance to participate in the study signing the informed consent Exclusion Criteria donor: * Potential future pregnancy desire. * Surgery for the treatment of…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Number of grafts obtained by laparoscopy

Timeframe: 2 years

Trial details

NCT IDNCT04314869

SponsorHospital Clinic of Barcelona

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-12

Contact for this trial

Mariona Rius, MD

932275400 marius@clinic.cat

View on ClinicalTrials.gov More Rokitansky Kuster Hauser Syndrome trials