Feasibility of Combined Focused Ultrasound and Radiotherapy Treatment in Patients With Painful Bone Metastasis

Inclusion Criteria: * Men and women with age ≥ 18 years * Patient capable of giving informed consent and able to attend study visits * Uncomplicated painful bone metastases * Weight \<140kg and able to fit in the MRI gantry * Radiologic evidence of bone metastases from any solid tumor * Pain is localized to the targeted area, or is likely to be referred pain arising from the targeted area * Pain related to the target lesion is refractory to less invasive treatments for pain relief * Multiple metastatic lesions, with one predominantly painful lesion (\>=2 points higher pain score than other lesions). The lesion should be clearly distinguishable from other painful lesions. * Device accessible tumors: extremities (excluding joints), pelvis, shoulders, posterior vertebral spine below L5, in selected cases ribs and sternum * Target lesion maximum dimension ≤ 8cm * Intended target volume visible by non-contrast MR imaging * Distance between target and skin ≥ 1cm * Numeric Rating Scale (NRS) score \>= 4 or equivalent * Life expectancy \>3 months Exclusion Criteria: * Planned treatment lesion is a primary bone tumor or due to lymphoma, multiple myeloma, or leukemia. * Communication barrier present * Patient enrolled in another clinical study related to bone metastases treatment or pain relief treatment * Unable to tolerate required stationary position during treatment despite adequate pain medication * Need for surgery * Pregnant woman * Pain related to target lesion is predominan…