A Study to Assess ASP0598 Otic Solution Following Topical Application in the Ear in Subjects With Chronic Tympanic Membrane Perforation (CTMP)

Inclusion Criteria: * Subject has chronic tympanic membrane perforation (CTMP) documented as persisting longer than 3 months. * A female subject is eligible to participate if she is not pregnant and at least one of the following conditions applies: * Not a woman of childbearing potential (WOCBP) OR * WOCBP who agrees to follow the contraceptive guidance starting at screening and for at least 28 days after investigational product (IP) application. * Female subject must agree not to breastfeed starting at drug application on Day 1 and for at least 28 days after IP application. * Female subject must not donate ova starting on Day 1 and for at least 28 days after investigational product (IP) application. * A male subject with female partner(s) of child-bearing potential must agree to use contraception starting on Day 1 and for at least 28 days after IP application. * A male subject must not donate sperm starting on Day 1 and for at least 28 days after IP application. * Male subject with a pregnant or breastfeeding partner(s) must agree to remain abstinent or use a condom from Day 1 and for at least 28 days after IP application. * Subject must be willing and able to comply with the study requirements including refraining from using prohibited concomitant medications. * Subject agrees not to participate in another interventional study during the study period. Exclusion Criteria: * Subject has one of following conditions that may affect the ipsilateral side of the ear with c…