UnknownNot Applicable

Measures of Mitochondria Dysfunction in PD

United States30 participantsStarted 2020-02-24

Plain-language summary

This study evaluates metabolic and functional parameters in the skeletal muscle of Parkinson's disease patients for comparison to a set of healthy age-matched controls.

Who can participate

Age range

65 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 65-85 years. * Ability to attend a 3-hour study visit in Seattle, WA. * Ability to read and speak English. * Hoehn \& Yahr Stage 2-3. (bilateral disease, not severely disabled.) Exclusion Criteria: * Any contra-indication to magnetic resonance imaging * A history of epilepsy, stroke, brain surgery, or structural brain disease. * The presence of other serious illnesses * Current or recent enrollment in a clinical trial involving an investigational product or device. * Supplementation with NAD, nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), and other nutraceuticals designed to target NAD for 30 days prior to baseline study visit. * Current drug or alcohol use or dependence. * Inability/unwillingness to provide informed consent. (e.g. diagnosis of dementia, confusion about study goals or participation.) * Acute infection (e.g. upper respiratory, dermal) in the previous 30 days. * Right limb tremor or dyskinesia that cannot be comfortably controlled for 90 minutes.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

ATPmax

Timeframe: baseline

NAD(H) metabolites

Timeframe: baseline

Muscle force and endurance

Timeframe: baseline

Trial details

NCT IDNCT04300608

SponsorUniversity of Washington

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-07

Contact for this trial

Sophia Liu, PhD

206-685-3533 sophia21@uw.edu

View on ClinicalTrials.gov More Parkinson Disease, Mitochondrial trials

Who can participate

Age range

65 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.