Effect of Lowering IOP in Glaucoma Suspects With HM (NCT04296916) | Clinical Trial Compass
UnknownNot Applicable
Effect of Lowering IOP in Glaucoma Suspects With HM
China264 participantsStarted 2020-04-17
Plain-language summary
Currently, whether and when intraocular pressure (IOP) lowering medication should be used in glaucoma suspects with high myopia (HM) is still a dilemma. Randomized trials are required to evaluate whether IOP lowering influences the incidence of glaucoma suspect progression in HM eyes.
Who can participate
Age range35 Years – 65 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Aged between 35 and 65 years.
✓. Diagnosed with high myopia (spherical equivalent ≤ -8.00 diopters or axial length ≥ 26.5 mm).
✓. Diagnosed with glaucoma suspect, which cannot be explained by myopic macular changes, or other retinal and neurologic condition.
✓. IOP ≥ 12 mmHg and ≤ 24mmHg on at least 2 visits, as measured by Goldmann applanation tonometry.
✓. An open anterior chamber angle as based upon gonioscopy.
✓. Best corrected visual acuity (BCVA) ≥ 6/12.
Exclusion criteria
✕. Allergy to prostaglandins.
✕. Advanced VF loss (MD worse than 16 dB) or a threat to fixation (sensitivity 10 dB or worse affecting either or both test points closest to the point of fixation in the upper hemifield and at either or both of the corresponding test points in the lower hemifield) in either eye.
✕. Previous IOP-lowering surgery in the study eye (i.e. trabeculectomy, Ahmed glaucoma valve implantation, any laser trabeculoplasty).
✕. Previous cataract surgery in the study eye.
✕. Previous corneal refractive surgery in the study eye.
✕. Clinically significant or progressive retinal disease such as proliferative diabetic retinopathy, retinal detachment, central retinal vein occlusion, or retinitis pigmentosa in the study eye.
What they're measuring
1
The number of subjects whose visual filed progressed during the follow up