Comparison of the Effects of Fentanyl, Oxycodone, Butorphanol on Gastrointestinal Function (NCT04295109) | Clinical Trial Compass
UnknownNot Applicable
Comparison of the Effects of Fentanyl, Oxycodone, Butorphanol on Gastrointestinal Function
China105 participantsStarted 2020-03-02
Plain-language summary
Postoperative ileus (POI) is a transient loss of coordinated peristalsis precipitated by surgery and exacerbated by opioid pain medication.So,how to provide patients with ideal analgesia without affecting the recovery of postoperative gastrointestinal function?This was a prospective randomized controlled study. A total of 105 patients who were scheduled for laparoscopic hysterectomy were randomly selected from The First Affiliated Hospital with Nanjing Medical University by random number table. These patients were randomly divided into three groups: fentanyl(F) group, oxycodone(O) group and butorphanol(B) group.
Who can participate
Age range40 Years – 65 Years
SexFEMALE
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Inclusion criteria
✓. patients who were scheduled for laparoscopic hysterectomy from W\&C BRANCH HOSPITAL OF JIANGSU PROVINCE HOSPITAL
✓. American Society of Anesthesiologists (ASA) physical status classification 1 to 2,
✓. Women aged 40-65
✓. Weight 50-80 kg
Exclusion criteria
✕. History of opioids abuse and allergy and contraindication to opioid drugs
✕. bronchial asthma; coronary heart disease; severe hypertension; diabetes mellitus;
✕. History of brain damage or psychiatric disease
✕. Patients with coagulopathy (PT\> 17 seconds or activated partial thromboplastin time (APTT)\> 47 seconds);
✕
What they're measuring
1
postoperative time to first anal exhaust
Timeframe: From date of operation until the date of discharge from hospital or date of death from any cause, whichever came first, assessed up to 15 days
2
the cumulative dose administered in the patient-controlled mode
Timeframe: From date of operation until the date of first documented progression of anal exhaust , assessed up to 48 hours
3
effective bolus times
Timeframe: From date of operation until the date of first documented progression of anal exhaust , assessed up to 48 hours
Trial details
NCT IDNCT04295109
SponsorThe First Affiliated Hospital with Nanjing Medical University