Open Label, Dose Escalation Study for the Safety and Efficacy of STP705 in Adult Patients With isSCC

Inclusion Criteria: * 1\. Male or female adult ≥ 18 years of age. * 2\. Primary, histologically confirmed trunk or extremity (non-peri-orbital/-anogenital/-facial/-scalp) isSCC lesion suitable for excision with a minimum diameter of 0.5cm and with a maximum diameter of 2.0cm. * 3\. Histological diagnosis made no more than 6 months prior to the screening visit. * 4\. Histological biopsy removed ≤25% of the original area of the target lesion. * 5\. No other dermatological disease in the isSCC target site or surrounding area, which in the opinion of the investigator, could interfere with the study. * 6\. Willing to refrain from using non-approved lotions or creams on the target site and surrounding area during the treatment period. * 7\. Willing to refrain from exposure to excessive direct sunlight or ultraviolet light and to avoid the use of tanning parlors for the duration of the study. * 8\. Laboratory values for the tests (listed in the Study Schedule) within the reference ranges as defined by the central laboratory, or "out of range" test results that is clinically acceptable to the investigator. Acceptable "out of range" values are generally those within 2 standard deviations of the mean or explainable due to concurrent medications or disease processes. * 9\. Ability to follow study instructions and likely to complete all study requirements. * 10\. Written informed consent obtained, including consent for tissue to be examined and stored by the Central Histology Lab. * 11\…