Background. Cardiopulmonary bypass in on-pump cardiac surgery (OPCS) can have harmful effects by ischemia-reperfusion. No data about the effects of remote ischemic postconditioning (RIP) in hypoxia-inducible factor-1 alpha (HIF-1α) plasma level after OPCS. The aim of this study is evaluate the effects of RIP on postoperative HIF-1α plasma levels, cardiac markers and arterial oxygenation of patients after OPCS. Methods. Randomised controlled study in 70 patients undergoing OPCS: 35 patients receive RIP (RIP group) and 35 patients not (control group). Patients receive RIP on upper limb: 5 min of ischemia followed by 5 min of reperfusion (3 cycles) immediately after leaving on-pump. The primary outcome was to know the HIF-1α plasma levels after surgery in both groups: before starting surgery (T0) and after CPB period at 2 h (T1), 8 h (T2), 24 h (T3), 36 h (T4), 48 h (T5). Secondary outcomes included to measure the cardiac markers levels (Troponin T, CK-MB, CPK), arterial oxygenation (PaO2/FiO2) and others.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Study of time course of HIF-1α plasma levels (absorbance units) after on-pump cardiac surgery
Timeframe: Before starting surgery, is the basal time (Time 0)
Study of time course of HIF-1α plasma levels (absorbance units) after on-pump cardiac surgery
Timeframe: 2 hours after cardiopulmonary bypass period (Time 1)
Study of time course of HIF-1α plasma levels (absorbance units) after on-pump cardiac surgery
Timeframe: 8 hours after cardiopulmonary bypass period (Time 2)
Study of time course of HIF-1α plasma levels (absorbance units) after cardiac surgery
Timeframe: 24 hours after cardiopulmonary bypass period (Time 3)
Study of time course of HIF-1α plasma levels (absorbance units) after on-pump cardiac surgery
Timeframe: 36 hours after cardiopulmonary bypass period (Time 4)
Study of time course of HIF-1α plasma levels (absorbance units) after on-pump cardiac surgery
Timeframe: 48 hours after cardiopulmonary bypass period (Time 5).