CompletedPhase 4

Applying Best Clinical Practices to Patients at High Risk of Respiratory Complications

United States12,248 participantsStarted 2022-02-18

Plain-language summary

The purpose of this study is to: 1. Perform a retrospective analysis on data contained in the UCLA Perioperative Data Warehouse on the incidence of respiratory dysfunction in the post-operative care unit (PACU) before and after the introduction of sugammadex into clinical practice. 2. Develop and implement a clinical best practice pathway designed to prevent postoperative respiratory complications in higher risk patients (such as those with OSA or preexisting respiratory disease) using education and clinical decision support in patients.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * UCLA Ronald Reagan or Santa Monica patients aged 18 and older who had a general anesthetic with either rocuronium or vecuronium. * Patients who receive sugammadex from the specified study supply Exclusion Criteria: * Patients under the age of 18 * Patients with a preoperative glomerular filtration rate less than 30 or on hemodialysis * Patients with known hypersensitivity to any of the following: rocuronium, vecuronium, sugammadex, neostigmine or glycopyrrolate * Patients with known neuromuscular disease * Patients who remain intubated after surgery or leave the operating room with a tracheostomy in-situ * Patients who did not receive reversal of neuromuscular blockade (with neostigmine in the pre-period or sugammadex in the post-period).

What they're measuring

Time to "Fitness for Discharge" From the Recovery Room

Timeframe: One year prior to study intervention to one year following implementation of study intervention

Incidence of Hypoxemia in the PACU (Oxygen Saturation Below 90%)

Timeframe: One year prior to study intervention to one year following implementation of study intervention

Trial details

NCT IDNCT04263363

SponsorUniversity of California, Los Angeles

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-05-07

Results submitted2025-05-07

View on ClinicalTrials.gov More Respiratory Complication trials

Plain-language summary

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Time to "Fitness for Discharge" From the Recovery Room

Timeframe: One year prior to study intervention to one year following implementation of study intervention

Incidence of Hypoxemia in the PACU (Oxygen Saturation Below 90%)

Timeframe: One year prior to study intervention to one year following implementation of study intervention