Acalabrutinib and Anti-CD19 CAR T-cell Therapy for the Treatment of B-cell Lymphoma

Inclusion Criteria: * Histologically confirmed large B-cell lymphoma, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, primary mediastinal large B-cell lymphoma, high grade B-cell lymphoma, and DLBCL arising from follicular lymphoma, and indolent (grade 1-3a) FL * Criteria must be met for receiving commercial axi-cel per Food and Drug Administration (FDA) label * \>= 18 years of age * Patients must be capable of understanding and providing a written informed consent * Negative serum pregnancy test within 2 days of initiating acalabrutinib for women of childbearing potential (WOCBP), defined as those who have not been surgically sterilized or who have not been free of menses for at least 1 year * Fertile male and WOCBP patients must be willing to use highly effective contraceptive methods before, during, and for at least 4 months after the CAR T-cell infusion or within 2 days of acalabrutinib, whichever is longer * Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 * Creatine clearance (CrCl) \> 50 mL/min or serum creatinine =\< 2.5 * Total bilirubin =\< 1.5x the upper limit of normal * Adequate pulmonary function, defined as =\< grade 1 dyspnea and oxygen saturation (SaO2) \>= 92% on room air * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 3x the upper limit of normal * Adequate cardiac function, defined as left ventricular ejection fraction (LVEF) of \>= 50% and without evidence for pericardial effusion * At…