CompletedNot Applicable

Impact of Interval Training on Sympathetic Hyperactivity and Vascular Function

Brazil35 participantsStarted 2015-01

Plain-language summary

In this study, the investigators are testing the hypothesis that reduction in sympathetic activity would be greater following high-intensity interval training (HIIT) than moderate-intensity continuous training (MICT) and correspond with improvements in peripheral vascular function, and skeletal muscle function in patients with heart failure with reduced ejection fraction (HFrEF).

Who can participate

Age range30 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Functional Class II to III of New York Heart Association * Left ventricular ejection fraction ≤40% * Peak oxygen uptake (V̇O2) \<20 ml•kg-1•min-1 Exclusion Criteria: * Myocardial infarction within three months * Unstable angina * Acute heart failure * Pacemaker * Pulmonary disease * Chronic renal disease * Peripheral neuropathy * History of stroke * Untreated hypo/hyperthyroidism * Body mass index (BMI) \>30 kg/m2 * History of smoking

What they're measuring

Change in muscle sympathetic nerve activity (MSNA)

Timeframe: Baseline and 12 weeks

Change muscle mechanoreceptor sensitivity

Timeframe: Baseline and 12 weeks

Change muscle metaboreceptor sensitivity

Timeframe: Baseline and 12 weeks

Change in chemoreceptor sensitivity

Timeframe: Baseline and 12 weeks

Trial details

NCT IDNCT04248894

SponsorUniversity of Sao Paulo General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-04

View on ClinicalTrials.gov More Heart Failure trials