The purpose of this study is to examine the mechanisms of brain injury contributing to postoperative neurocognitive disorders (PNCD) in an at-risk population (obstructive sleep apnea (OSA)) undergoing surgery. The investigators will enroll 50 OSA patients scheduled for surgery. All patients will have a brain scan (fMRI) within five days before surgery and two days and six months after surgery. During this visit cognitive function will be assessed using the Wide Range Assessment of Memory and Learning (WRAML2) and Montreal Cognitive Assessment (MoCA) tests. Patients will also be asked to participate in a blood draw during the first 2 visits for fMRI (within five days of surgery and two days after surgery). The Confusion Assessment Method (CAM-S) test, will be used to examine postoperative delirium.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Preoperative cognitive function
Timeframe: pre-surgery (within five days before)
Postoperative cognitive dysfunction - delayed cognitive recovery
Timeframe: Post-surgery (within two days post surgery).
Postoperative cognitive dysfunction - neurocognitive disorder
Timeframe: Post-surgery (6 months after surgery).
Preoperative cognitive function II
Timeframe: pre-surgery (within five days before surgery)
Postoperative cognitive dysfunction - delayed cognitive recovery II
Timeframe: Post-surgery (within two days post surgery).
Postoperative cognitive dysfunction - neurocognitive disorder II
Timeframe: Post-surgery (6 months after surgery).
Postoperative Delirium
Timeframe: A two times per day for up to three days or discharge from the hospital.