Biopsy Collection for Men Undergoing Brachytherapy for Prostate Cancer (NCT04243473) | Clinical Trial Compass
WithdrawnNot Applicable
Biopsy Collection for Men Undergoing Brachytherapy for Prostate Cancer
Stopped: The study team decided to not move forward with enrolling patients because funding was not identified to support the project.
United States0Started 2026-01
Plain-language summary
The primary goal of this tissue collection protocol is to establish a framework for the acquisition and banking of biospecimen collected from men undergoing brachytherapy. Biopsies of the prostate is an invasive procedure; however, in this tissue collection protocol, biopsies are acquired intraoperatively while patients are prepped for brachytherapy seed placement, thus minimizing the inconvenience of the biopsy procedure for patients. The utility of these biopsies will provide a valuable resource for molecular assessments.
Who can participate
Age range18 Years – 100 Years
SexMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Newly diagnosed prostate cancer within the past 12 months:
✓. The patient has decided to undergo brachytherapy as treatment modality for his prostate cancer.
✓. Suitable volume of disease for biopsy, defined as one or more of the following:
✓. Identifiable lesions of greater or equal to one
✓. Clinically palpable disease corresponding to (ipsilateral to) any involved core on biopsy OR
✓. ≥50% of biopsy cores involved with cancer
✓. Patients or their legal representatives must have the ability to read, understand and provide written informed consent for the initiation of any study related procedures.
✓. Males 18 years of age or older
Exclusion criteria
✕. Prior history of any other malignancy which was either newly diagnosed or recurred (following prior curative treatment) within last 2 years, other than non-melanoma skin carcinoma.
What they're measuring
1
Acquisition and banking of biospecimen collected from men undergoing brachytherapy
Timeframe: Up to 2 years post-implant at confirmatory biopsy
Trial details
NCT IDNCT04243473
SponsorSidney Kimmel Comprehensive Cancer Center at Johns Hopkins
✕. Major medical or psychiatric illness which, in the investigator's opinion, would prevent completion of treatment and would interfere with follow up.