Clinical Trial to Evaluate the Efficacy of Fecal Microbiota Transplantation in Patients With Alopecia Areata

Inclusion Criteria: * Patients 18 to 75 years of age with moderate to severe alopecia areata (SALT score \>30%) * Patients with a diagnosis of patch type alopecia areata, totalis, or universalis. * Duration of hair loss greater than 3 months. * No evidence of active, ongoing regrowth present at baseline. * Females of childbearing potential must have a negative urine or serum pregnancy test at screening and immediately prior to FMT on the day of FMT, and * Females of childbearing potential must agree to use an effective form of contraception from 14 days prior to study antibiotics through at least 30 days after FMT. Acceptable forms of contraception include Oral/intramuscular (IM) contraceptives, intrauterine device (IUD), surgical sterilization. Exclusion Criteria: * Inability (e.g. dysphagia) to or unwilling to swallow capsules * Active gastrointestinal infection at time of enrollment * Patient received antibiotics in the last 48 hours. Patients will be eligible to enroll if antibiotic therapy is discontinued for at minimum 48 hours prior to treatment. * Requires continued antibiotic use or anticipates antibiotic use in the upcoming 4 weeks * Known or suspected toxic megacolon and/or known small bowel ileus * Major gastrointestinal surgery (e.g. significant bowel resection) within 3 months before enrollment. This does not include appendectomy or cholecystectomy * History of total colectomy or bariatric surgery * Concurrent intensive induction chemotherapy, radiation thera…