Ketogenic Diet in Patients With Untreated Low Tumor Burden Mantle Cell Lymphoma

Inclusion Criteria: * Histologically confirmed diagnosis of mantle cell lymphoma * Age ≥ 18 years * No prior systemic therapy for lymphoma * ECOG performance status ≤ 2 * Required initial laboratory parameters: * Absolute neutrophil count (ANC) ≥ 1000 cells/mm3 * Platelet count ≥ 75,000 cells/mm3 * Calculated creatinine clearance ≥ 30 ml/min by Cockcroft-Gault formula * Total bilirubin ≤ 2.0 x ULN * AST/SGOT or ALT/SGPT ≤ 3.0 x ULN * Understand and voluntarily sign an ICF prior to any study related assessments and procedures are conducted Exclusion Criteria: * Patients with blastoid histology * Patients with known or suspected central nervous system (CNS) involvement * Patients with a clear indication for treatment of lymphoma, including those with a tumor larger than 6 cm, more than 3 lymph nodes more than 3 cm, or constitutional symptoms * Active viral infection with HIV or hepatitis type B or C. Seropositive HBV patients are eligible if they are negative for HBV DNA by PCR and receive concomitant antiviral therapy during treatment and for additional six months after coming off study. * Active uncontrolled systemic fungal, bacterial or viral infection (defined as ongoing signs/symptoms related to the infection without improvement despite appropriate antibiotics, antiviral therapy and/or other treatment) * Uncontrolled moderate to severe hypertriglyceridemia (TG\>300 mg/dL). * Strong family history of hypertriglyceridemia and coronary artery disease. * Myocardi…