Pharmacokinetics, Subjective Effects, and Abuse Liability of Nicotine Salt-Based Vaping Products With Tobacco or Unflavored E-liquids, SALTVAPE Study

Inclusion Criteria: * Willingness to abstain from using ENDS product for 8-10 hours (overnight abstinence) prior to study visits * Current daily ENDS user as determined by * Has used ENDS product every day for the past 6 months (by history) * Has used ENDS product or e-liquid containing nicotine (by history) * Participant or legal representative must understand the investigational nature of this study and sign and Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure Exclusion Criteria: * Smoked cigarettes in the past 7 days * Currently smokes \>= 5 cigarettes per month * Unstable medical conditions (such as unstable heart disease, uncontrolled hypertension, thyroid disease, diabetes, renal or liver impairment, or glaucoma) or psychiatric condition (such as current major depression, history of schizophrenia or bipolar disorder) or current regular use of psychiatric medications (such as major tranquilizers and antidepressants) * History of serious side effects from nicotine or from any nicotine replacement therapies * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * Pregnant or nursing females * Concurrent participation in another clinical trial * Unwilling or un…