Greater Trochanteric Pain Syndrome: Efficacy of Ultrasound Guided Platelet-rich Plasma vs Needle … (NCT04231357) | Clinical Trial Compass
CompletedPhase 3
Greater Trochanteric Pain Syndrome: Efficacy of Ultrasound Guided Platelet-rich Plasma vs Needle Tenotomy.
Spain81 participantsStarted 2019-12-04
Plain-language summary
Great trochanteric pain syndrome (GTPS) is a difficult problem to manage and results in significant patient morbidity. This study is a single-center, randomized double-blind controlled trial. Eighty patients will be allocated to have an ultrasound (US)-guided injection of pure platelet-rich plasma (PRP) or needle tenotomy. Outcome data will be collected before the intervention, and at 3, 6, and 12 months after intervention. Main outcome measure: percent of patients that experience a reduction of 25% in hip outcome score (HOS) (responders) at 6 months after the intervention. Secondary outcome measures include percent of responders at three and twelve months, and pain reduction (VAS) at 3, 6, and 12 months. Adverse reactions or events will be recorded.
Who can participate
Age range35 Years – 75 Years
SexALL
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Inclusion Criteria:
* Patients of both sexes between the ages of 35 and 75 years.
* At the screening visit, they present hip pain at 3 points out of 10 in EVA.
* Body Mass Index values between 20 and 35 (both values included).
* Commitment to comply with all study procedures.
* Diagnoses of chronic GTPS according to the diagnostic criteria that have been previously described.
* The patient must give written informed consent.
* Women of child-bearing age must obtain a negative test result of pregnancy in blood or urine and accept the use of appropriate contraception while in the trial.
Exclusion Criteria:
* • Body Mass Index\>35.
* Presence of full tendon tear.
* Systemic autoimmune rheumatologic disease (connective tissue diseases and systemic necrotizing vasculitis)
* Poorly controlled diabetes mellitus (glycosylated hemoglobin above 9%)
* Blood disorders (thrombopathy, thrombocytopenia, anemia with Hb \<9)
* Patients receiving immunosuppressive treatments
* Treatment by intramuscular corticoid, during the 3 months prior to the first administration of the trial treatment.
* Treatment with non-steroidal anti-inflammatory drugs (more than 10 days consecutive to usual doses), opiates or oral steroids during the 15 days prior to treatment in the study.
* Severe heart disease
* Patients unable to comply with scheduled visits, for work or spend long periods away from their habitual residence.
* Patients with active cancer or cancer diagnosed in the last fiv…
What they're measuring
1
Rate of participants that showed a clinically minimal clinically important change in function as measured by HOS (Hip Outcome Score, Activity of Daily Living Scale)