Phase 1 Three Part SAD, MAD & Cross-Over Study of ZP-059 in Healthy and Asthmatic Subjects

Inclusion Criteria (part 1): * Female subjects must be either of non-childbearing potential or if of childbearing potential use a highly effective birth control method * Male subjects with female partners of childbearing potential must be vasectomised with documented medical assessment of the surgical success or use highly effective contraception together with their female partner(s) * Subject must agree not to donate semen or ova/oocytes during the study and for 14 days after the last dose of IMP. * BMI ≥ 18.0 and ≤ 35.0 kg/m2 at Screening. * Are willing and able to comply with all aspects of the protocol. * FEV1 ≥80% of the predicted value and FEV1/FVC ratio \> 0.70; at screening. * Able to demonstrate the correct inhalation technique for use of delivery device during the study at screening and pre-dose Day 1. Inclusion Criteria (part 2): * Subjects with mild stable asthma with a documented physician confirmed diagnosis of asthma for at least 3 months prior to screening. * Asthma assessed by investigator as being stable for at least 4 weeks prior to screening and prior to Day 1. * Female subjects must be either of non-childbearing potential or if of childbearing potential use a highly effective birth control method * Male subjects with female partners of childbearing potential must be vasectomised with documented medical assessment of the surgical success or use highly effective contraception together with their female partner(s). * Subject must agree not to donate semen…