Amplatzer Amulet LAAO vs. NOAC

Inclusion Criteria: * Documented paroxysmal, persistent, or permanent non-valvular AF (documentation must include an electrocardiogram, Holter, or event recorder) * At high risk of stroke or systemic embolism, defined as a CHA2DS2-VASc score of ≥ 2 for men and ≥ 3 for women * Eligible for long-term NOAC therapy * Able to comply with the required NOAC medication regimen if randomized to the Control Group * Able to comply with the required medication regimen post-device implant if subject is randomized to the Device Group or subject is a Roll-in * Able to understand, and is willing to provide, written informed consent to participate in the trial, prior to any clinical investigation related procedure or assessment * 18 years of age or older, or the age of legal consent * Able and willing to return for required follow-up visits and assessments Exclusion Criteria: * Requires long-term OAC therapy for a condition other than AF * Planned cardiac intervention or surgery, which is invasive or requires sedation or anesthesia, within 3 months following randomization, other than study-related procedures such as LAAO and cardiac imaging (if applicable) * Known contraindication to, or allergic to, aspirin, clopidogrel, or OAC medication use * Indicated for P2Y12 platelet inhibitor for \>1 year post-randomization * In the opinion of the investigator, is considered at high risk for general anesthesia and general anesthesia is planned for the study procedure * Has undergone atrial septal d…