Olfactory Odour Stimulation for Metabolism Control (NCT04223284) | Clinical Trial Compass
CompletedNot Applicable
Olfactory Odour Stimulation for Metabolism Control
Switzerland41 participantsStarted 2019-12-10
Plain-language summary
In this preliminary short-term study it is investigated, whether a short olfactory stimulation with D-Limonene leads to an acute improvement of glucose metabolism in patients with obesity.
Who can participate
Age range18 Years – 70 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18-70 years
* Obesity (BMI ≥35 kg/m2)
* Written informed consent
* Normosmia (defined by sniffin Sticks test)
Exclusion Criteria:
* Known allergy to D-Limonene, citrus fruits, citrus flavours, SLVO
* Regular smoking
* Current illicit drug abuse including daily marijuana and cannabidiol (CBD) consumption (alcohol ≤2 drinks per day allowed)
* Diabetes mellitus
* Pre-Treatment with insulin sensitizing drugs including GLP-1 analogues
* History of neurodegenerative diseases, severe head trauma
* Severe renal impairment (e.g. estimated glomerular filtration rate \<30 ml/min/m2)
* Known liver cirrhosis or other severe liver impairment
* Acute upper respiratory tract infection
* Uncontrolled dysthyroidism
* Uncontrolled hypertension
* Regular use of psychopharmaceutic drugs
* Patient aims to start a new diet or exercise program during the study
* Bariatric surgery
* Pregnancy/Lactation
* Symptoms of menopause
* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
* Participation in an interventional study within the last 3 months
What they're measuring
1
Change of area under blood glucose curve (AUBGC)
Timeframe: Time Frame: baseline blood exam (timepoint 0) and further blood collections: 5, 15, 30, 60, 90 and 120 minutes after drinking a standardized mixed-meal solution