Cultures Before and After Decolonization in Community Dwelling Adults With Current S. Aureus Colonization

Inclusion Criteria: * Veteran living in the greater Baltimore, MD area * Adults \>= 18 years of age * Living independently * Willing and able to provide anterior nares, skin, throat, and perirectal specimens over an 18 week time period. * Willing and able to administer intranasal mupirocin and topical chlorhexidine over a five day period * Capable of understanding and complying with the entire study protocol. * Provided signed and dated informed consent Exclusion Criteria: * Use of anticancer chemotherapy or radiation therapy (cytotoxic) within the past 6 months * History of HIV infection with most recent CD4 of \<200 * Immunosuppression medications within the past 3 months * Use of systemic antibacterial or antifungal agents in the past 3 months * Use of nasal steroids currently or in the past 3 months * Use of nasal antimicrobial ointment in the past 3 months * Any current indwelling percutaneous medical device or urinary catheter * Acute care hospitalization in the past 3 months * Planned surgery or hospitalization during the study period * History of an allergic reaction to chlorhexidine or mupirocin * Oral temperature of \>100 F at enrollment visit * BMI \<18 or \>35 at enrollment visit