Trial Testing Safety of IL-21 NK Cells for Induction of R/R AML

Inclusion Criteria: Patient Inclusion Criteria for Induction Phase * Primary Relapsed AML including * Relapsed AML after allogeneic stem cells * Isolated CNS or extramedullary disease (Note: a response monitoring plan must be developed a priori for subjects with extramedullary disease) * 1-3 prior lines of therapy which includes chemotherapy, hypomethylating agents, venetoclax or targeted therapy. * Patient weight ≥ 42 kg * Performance status: Karnofsky or Lansky Performance Scale (PS) greater or equal to 70, or, ECOG score 0-2. * Renal function: Serum creatinine ≤ 2 mg/dl and/or creatinine clearance greater or equal than 40 cc/min. * Pulmonary function: FEV1, FVC and DLCO ≥ 50% of expected, corrected for hemoglobin. * Liver function: Total bilirubin ≤ 2 mg/dl or ≤ 2.5 x ULN for age (unless Gilbert's syndrome) and SGPT (ALT) ≤ 2.5 x ULN for age. * Cardiac function: left ventricular ejection fraction ≥ 40%. * CNS: Patients with seizure disorder are eligible if seizures well controlled. * Negative serum test to rule out pregnancy within 2 weeks prior to enrollment in females of childbearing potential (non-childbearing potential defined as premenarchal, greater than one year post-menopausal, or surgically sterilized). * Sexually active males and females of childbearing potential must agree to use a form of contraception considered effective and medically acceptable by the Investigator. * Ability to understand and willingness to sign the written informed consent document. * Neg…