Study of VE800 and Nivolumab in Patients With Selected Types of Advanced or Metastatic Cancer

Partial Inclusion Criteria: * Patients with advanced or metastatic cancer who had received no more than 3 lines of prior systemic therapy for advanced/metastatic disease. * Histologically diagnosed advanced (unresectable) or metastatic cancer with at least one measurable lesion as per RECIST 1.1 * Tumor lesions amenable for biopsy, if deemed safe by the investigator * Toxicity from prior cancer therapy should have resolved to Common Terminology Criteria for Adverse Events (CTCAE) Grade ≤ 1 (excluding alopecia and neuropathy, where up to Grade 2 residual was allowed) Partial Exclusion Criteria: * Prior treatment with immune checkpoint inhibitor (iCPI) (Note: this criterion did not apply to patients with melanoma) * Receipt of any conventional or investigational systemic anti-cancer therapy within 21 days prior to the first dose of vancomycin * Concurrent chemotherapy, immunotherapy, biologic, or hormonal anti-cancer therapy. Agents such as bisphosphonates or denosumab were acceptable as prophylaxis for bone metastasis. * Patients must not have received a transfusion (platelets or red blood cells) within 4 weeks of the first dose of study treatment * Patients with an active, known or suspected autoimmune disease. Patients with type I diabetes mellitus, hypothyroidism only requiring hormone replacement, skin disorders (such as vitiligo, psoriasis, or alopecia) not requiring systemic treatment were permitted to enroll. * Patients with known active hepatitis (e.g., hepatitis B …