Loss of muscle can be caused by a variety of stimuli and results in reduced mobility and strength and also impacts whole body health. Whilst it is known that muscles waste the process by which this occurs is not well understood. Furthermore, whilst some muscles waste quickly others seem resistant to the effects of disuse. This study aims to evaluate how quickly changes in muscles start to occur, and investigate the processes which underlie muscle atrophy. By studying muscles which waste quickly and those which are resistant to atrophy this study aims to identify the different processes which lead to muscle loss. This study will also evaluate the differences in muscle changes between young and old people.
Age range
18 Years – 80 Years
Sex
MALE
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Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Changes in muscle volume (cm3)
Timeframe: 14 days in group 1. 5 days in groups 2 and 3
Changes in muscle thickness (cm)
Timeframe: 14 days in group 1. 5 days in groups 2 and 3
Changes in muscle cross surface area (cm2)
Timeframe: 14 days in group 1. 5 days in groups 2 and 3
Changes in muscle fibre length (cm)
Timeframe: 14 days in group 1. 5 days in groups 2 and 3
Changes in muscle fibre pennation angle (degrees)
Timeframe: 14 days in group 1. 5 days in groups 2 and 3
Muscle Protein Synthesis (MPS) rate (%/hr)
Timeframe: Over 8 hours following immobilisation period
Muscle Protein Breakdown (MPB) rate (%/hr)
Timeframe: Over 8 hours following immobilisation period